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COVID-19 (severe respiratory symptoms vs population)

near LZTFL1 · rs13078854

What the study found

Who was studied 1,128 European ancestry cases, 679,531 European ancestry controls, 245 Hispanic or Latin American cases, 94,237 Hispanic or Latin American controls, 74 Black or African American cases, 22,383 Black or African American controls.

The effect Each copy of the G allele carried 0.59 times the odds of COVID-19 (severe respiratory symptoms vs population) (95% confidence interval 0.527-0.665); p = 2 × 10−18.

Where it sits Chromosome 3, band 3p21.31 — between genes, 2.9 kb from LZTFL1.

What each result means

A/A No copy of the version the research linked to COVID-19 (severe respiratory symptoms vs population). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to COVID-19 (severe respiratory symptoms vs population). That is a smaller link than two copies.
G/G Two copies of the version the research linked to COVID-19 (severe respiratory symptoms vs population). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs13078854

What is rs13078854?

rs13078854 is a single position in the genome, in or near the near LZTFL1 gene. Published research associates it with covid-19 (severe respiratory symptoms vs population). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13078854 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13078854 come from?

GWAS Catalog, Nature genetics 2021, PMID:33888907. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (severe respiratory symptoms vs population) (rs13078854). MyGeneLog™. https://www.mygenelog.com/variants/rs13078854

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