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Chronotype

TMEM108 · rs13065394

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10−11.

How common The G allele had a frequency of about 71% in the people studied.

Where it sits Chromosome 3, band 3q22.1 — in an intron of TMEM108.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronotype compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronotype.
T/T Published research associates this genotype with typical/baseline likelihood of Chronotype — no copies of the reported risk allele.
Source

Questions about rs13065394

What is rs13065394?

rs13065394 is a single position in the genome, in or near the TMEM108 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13065394 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13065394 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronotype (rs13065394). MyGeneLog™. https://www.mygenelog.com/variants/rs13065394

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