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Liver enzyme levels (gamma-glutamyl transferase)

MYO1B · rs13030978

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 3.7 % higher (95% confidence interval 2.80-4.6); p = 1 × 10⁻¹¹.

How common The T allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 2, band 2q32.3 — in an intron of MYO1B.

What each result means

C/C No copy of the version the research linked to Liver enzyme levels (gamma-glutamyl transferase). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Liver enzyme levels (gamma-glutamyl transferase). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Liver enzyme levels (gamma-glutamyl transferase). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G

and 124 more — show all

Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS

Alcohol Genome-wide Association (AlcGen) Consortium · Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study · Genetic Investigation of Anthropometric Traits (GIANT) Consortium · Global Lipids Genetics Consortium · Genetics of Liver Disease (GOLD) Consortium · International Consortium for Blood Pressure (ICBP-GWAS) · Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)

Nature genetics · 2011 · PMID 22001757

Questions about rs13030978

What is rs13030978?

rs13030978 is a single position in the genome, in or near the MYO1B gene. Published research associates it with liver enzyme levels (gamma-glutamyl transferase). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13030978 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13030978 come from?

GWAS Catalog, Nature genetics 2011, PMID:22001757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Liver enzyme levels (gamma-glutamyl transferase) (rs13030978). MyGeneLog™. https://www.mygenelog.com/variants/rs13030978

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