LRP1B · rs13008705
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 181,587 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.0295 lower (95% confidence interval 0.019-0.04); p = 9 × 10−9.
How common The A allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 2, band 2q22.2 — in an intron of LRP1B.
rs13008705 is a single position in the genome, in or near the LRP1B gene. Published research associates it with symbol digit substitution test performance (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Symbol digit substitution test performance (baseline) (rs13008705). MyGeneLog™. https://www.mygenelog.com/variants/rs13008705