Gene Knowledge Graph
UTC
Sensitive

Breast cancer (estrogen-receptor positive)

near TNP1 · rs12998806

Where this position leads

Condition: Breast Cancer

rs12998806 Condition: Breast Cancer Breast Cancer Condition rs12998806 rs12998806 near TNP1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Breast cancer (estrogen-receptor positive) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Breast cancer (estrogen-receptor positive).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Breast cancer (estrogen-receptor positive) compared to the general population.
Source
Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer
Huo D, Feng Y, Haddad S, Zheng Y, Yao S, Han YJ, Ogundiran TO, Adebamowo C, Ojengbede O, Falusi AG, Zheng W, Blot W
and 35 more — show all
Cai Q, Signorello L, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Nathanson KL, Domchek SM, Rebbeck TR, Ruiz-Narváez EA, Sucheston-Campbell LE, Bensen JT, Simon MS, Hennis A, Nemesure B, Leske MC, Ambs S, Chen LS, Qian F, Gamazon ER, Lunetta KL, Cox NJ, Chanock SJ, Kolonel LN, Olshan AF, Ambrosone CB, Olopade OI, Palmer JR, Haiman CA
Human molecular genetics · 2016 · PMID 28171663

Questions about rs12998806

What is rs12998806?

rs12998806 is a single position in the genome, in or near the near TNP1 gene. Published research associates it with breast cancer (estrogen-receptor positive). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12998806 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12998806 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12998806 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:28171663. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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