LRP2 · rs12988804
Where this position leads
Condition: Multiple Sclerosis
What the study found
Who was studied 268 cases; replicated in 181 cases.
The effect Each copy of the T allele carried 2.18 times the odds of Relapse in multiple sclerosis (95% confidence interval 1.91-2.45); p = 3 × 10−8.
Where it sits Chromosome 2, band 2q31.1 — in an intron of LRP2.
rs12988804 is a single position in the genome, in or near the LRP2 gene. Published research associates it with relapse in multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, J Neurol Neurosurg Psychiatry 2017, PMID:28739605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Relapse in multiple sclerosis (rs12988804). MyGeneLog™. https://www.mygenelog.com/variants/rs12988804