Sensitive

Colorectal cancer

MAMSTR · rs12979278

Where this position leads

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Colorectal cancer — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2019, PMID:31089142)

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Colorectal cancer. (GWAS Catalog, Nat Commun 2019, PMID:31089142)

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Colorectal cancer compared to the general population. (GWAS Catalog, Nat Commun 2019, PMID:31089142)

Source

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A

and 86 more — show all

Penegar S, Theodoratou E, Vaughan-Shaw P, Campbell H, Zgaga L, Hayward C, Campbell A, Harris S, Deary IJ, Starr J, Gatcombe L, Pinna M, Briggs S, Martin L, Jaeger E, Sharma-Oates A, East J, Leedham S, Arnold R, Johnstone E, Wang H, Kerr D, Kerr R, Maughan T, Kaplan R, Al-Tassan N, Palin K, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Buchanan DD, Win AK, Hopper J, Jenkins ME, Lindor NM, Newcomb PA, Gallinger S, Duggan D, Casey G, Hoffmann P, Nöthen MM, Jöckel KH, Easton DF, Pharoah PDP, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Harkin A, Allan K, McQueen J, Paul J, Iveson T, Saunders M, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H, Kirac I, Matošević P, Hofer P, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Houlston RS, Dunlop MG

PRACTICAL consortium

Nature communications · 2019 · PMID 31089142 · open access

Questions about rs12979278

What is rs12979278?

rs12979278 is a single position in the genome, in or near the MAMSTR gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12979278 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12979278 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12979278 come from?

GWAS Catalog, Nat Commun 2019, PMID:31089142. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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