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Who was studied 90,888 European ancestry cases, 263,673 European ancestry controls.
The effect
Each copy of the C allele carried 0.93 times the odds of Idiopathic knee osteoarthritis (95% confidence interval 0.91-0.95); p = 2 × 10−11.
How common The C allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 19, band 19p13.2 — in an intron of C19orf38.
What each result means
C/CTwo copies of the version the research linked to Idiopathic knee osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Idiopathic knee osteoarthritis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Idiopathic knee osteoarthritis. This is the starting point the study compared everyone against.
Osteoarthritis and cartilage · 2023 · PMID 37247657
Questions about rs12978481
What is rs12978481?
rs12978481 is a single position in the genome, in or near the C19orf38 gene. Published research associates it with idiopathic knee osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12978481 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12978481 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12978481 come from?
GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:37247657. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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