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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 5,367 Icelandic ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.58 higher (95% confidence interval 0.41-0.75); p = 4 × 10−11.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 19, band 19q13.31 — between genes, 1.8 kb from CD177.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum levels of protein PCDHGA1 compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum levels of protein PCDHGA1.
G/GPublished research associates this genotype with typical/baseline likelihood of Serum levels of protein PCDHGA1 — no copies of the reported risk allele.
Nature communications · 2022 · PMID 35078996 · open access
Questions about rs12975477
What is rs12975477?
rs12975477 is a single position in the genome, in or near the near CD177 gene. Published research associates it with serum levels of protein pcdhga1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12975477 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12975477 come from?
GWAS Catalog, Nature communications 2022, PMID:35078996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Serum levels of protein PCDHGA1 (rs12975477). MyGeneLog™. https://www.mygenelog.com/variants/rs12975477