0 8125Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 80,265 European and unknown ancestry cases, 305,011 European and unknown ancestry controls.
The effect
Each copy of the C allele carried 1.04 times the odds of Gastroesophageal reflux disease (95% confidence interval 1.0248-1.0492); p = 2 × 10−9.
Where it sits Chromosome 19, band 19p13.11 — in an intron of KLHL26.
What each result means
C/CTwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31527586 · open access
Questions about rs12974777
What is rs12974777?
rs12974777 is a single position in the genome, in or near the KLHL26 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12974777 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12974777 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12974777 come from?
GWAS Catalog, Nature communications 2019, PMID:31527586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 8125Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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