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Who was studied 38,937 European ancestry morning chronotype individuals, 50,346 European ancestry evening chronotype individuals.
The effect
Each copy of the A allele carried 1.06 times the odds of Morning vs. evening chronotype (95% confidence interval -); p = 2 × 10−8.
How common The A allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 18, band 18q12.1 — in an intron of NOL4.
What each result means
A/ATwo copies of the version the research linked to Morning vs. evening chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Morning vs. evening chronotype. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Morning vs. evening chronotype. This is the starting point the study compared everyone against.
Nature communications · 2016 · PMID 26835600 · open access
Questions about rs12965577
What is rs12965577?
rs12965577 is a single position in the genome, in or near the NOL4 gene. Published research associates it with morning vs. evening chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12965577 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs12965577 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12965577 come from?
GWAS Catalog, Nat Commun 2016, PMID:26835600. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Morning vs. evening chronotype (rs12965577). MyGeneLog™. https://www.mygenelog.com/variants/rs12965577