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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 497 European ancestry cases, 2,387 European ancestry controls; replicated in 1,050 European ancestry cases, 2,510 European ancestry controls.
The effect
Each copy of the G allele carried 1.90 times the odds of Food allergy (95% confidence interval -); p = 2 × 10−8.
How common The G allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 18, band 18q21.33 — in an intron of SERPINB7.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Food allergy — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Food allergy.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Food allergy compared to the general population.
Nature communications · 2017 · PMID 29051540 · open access
Questions about rs12964116
What is rs12964116?
rs12964116 is a single position in the genome, in or near the SERPINB7 gene. Published research associates it with food allergy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12964116 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12964116 come from?
GWAS Catalog, Nat Commun 2017, PMID:29051540. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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