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Body mass index x sex x age interaction (4df test)

MC4R · rs12955983

Where this position leads

Condition: Obesity and Body Weight

rs12955983 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs12955983 rs12955983 MC4R

What the study found

Who was studied up to 51,625 European ancestry men aged <50, up to 60,654 European ancestry women aged <50, up to 90,988 European ancestry men aged >50, up to 106,622 European ancestry women aged >50.

The effect The reported allele is G; the catalogue records no effect size ; p = 9 × 10−60.

How common The G allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 18, band 18q21.32 — between genes, 7.3 kb from LOC342784.

What each result means

A/A No copy of the version the research linked to Body mass index x sex x age interaction (4df test). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Body mass index x sex x age interaction (4df test). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Body mass index x sex x age interaction (4df test). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs12955983

What is rs12955983?

rs12955983 is a single position in the genome, in or near the MC4R gene. Published research associates it with body mass index x sex x age interaction (4df test). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12955983 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs12955983 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12955983 come from?

GWAS Catalog, PLoS Genet 2015, PMID:26426971. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index x sex x age interaction (4df test) (rs12955983). MyGeneLog™. https://www.mygenelog.com/variants/rs12955983

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