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Atrial fibrillation and flutter (PheCode 427.2)

near GSDMB · rs12950209

Where this position leads

Condition: Atrial Fibrillation

rs12950209 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs12950209 rs12950209 near GSDMB

What the study found

Who was studied 9,482 African American or Afro-Caribbean cases, 109,200 African American or Afro-Caribbean controls, 4,250 Hispanic or Latin American cases, 54,584 Hispanic or Latin American controls, 416 East Asian ancestry cases, 6,327 East Asian ancestry controls, 74,152 European ancestry cases, 363,596 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0413 higher (95% confidence interval 0.029-0.054); p = 4 × 10−11.

How common The T allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 17, band 17q21.1 — between genes, 11.7 kb from GSDMB.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Atrial fibrillation and flutter (PheCode 427.2) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atrial fibrillation and flutter (PheCode 427.2).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atrial fibrillation and flutter (PheCode 427.2) compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs12950209

What is rs12950209?

rs12950209 is a single position in the genome, in or near the near GSDMB gene. Published research associates it with atrial fibrillation and flutter (phecode 427.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12950209 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs12950209 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12950209 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation and flutter (PheCode 427.2) (rs12950209). MyGeneLog™. https://www.mygenelog.com/variants/rs12950209

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