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Who was studied at least 757,601 European ancestry individuals (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the G allele shifted the measure 0.0186 lower (95% confidence interval 0.012-0.025); p = 7 × 10−9.
Where it sits Chromosome 17, band 17p13.1 — in an intron of TP53.
What each result means
A/ANo copy of the version the research linked to Diastolic blood pressure (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Diastolic blood pressure (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Diastolic blood pressure (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs12949655
What is rs12949655?
rs12949655 is a single position in the genome, in or near the TP53 gene. Published research associates it with diastolic blood pressure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12949655 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs12949655 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12949655 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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