Standard
Adolescent idiopathic scoliosis (severe)
SOX9 · rs12946942
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of Adolescent idiopathic scoliosis (severe) — no copies of the reported risk allele.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Adolescent idiopathic scoliosis (severe).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Adolescent idiopathic scoliosis (severe) compared to the general population.
Source
Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3
Miyake A,
Kou I,
Takahashi Y,
Johnson TA,
Ogura Y,
Dai J,
Qiu X,
Takahashi A,
Jiang H,
Yan H,
Kono K,
Kawakami N
and 19 more — show all
Uno K,
Ito M,
Minami S,
Yanagida H,
Taneichi H,
Hosono N,
Tsuji T,
Suzuki T,
Sudo H,
Kotani T,
Yonezawa I,
Kubo M,
Tsunoda T,
Watanabe K,
Chiba K,
Toyama Y,
Qiu Y,
Matsumoto M,
Ikegawa S
PloS one · 2013 · PMID 24023777 · open access
Questions about rs12946942
What is rs12946942?
rs12946942 is a single position in the genome, in or near the SOX9 gene. Published research associates it with adolescent idiopathic scoliosis (severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12946942 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12946942 come from?
GWAS Catalog, PLoS One 2013, PMID:24023777. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants