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Who was studied 34,433 European ancestry individuals; replicated in Up to 100,347 European ancestry individuals, up to 12,889 Indian Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.57 mm Hg higher (95% confidence interval 0.37-0.77); p = 1 × 10−8.
How common The T allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of PLCD3.
What each result means
A/ANo copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs12946454
What is rs12946454?
rs12946454 is a single position in the genome, in or near the ACBD4 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12946454 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs12946454?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs12946454 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12946454 come from?
GWAS Catalog, Nat Genet 2009, PMID:19430483. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 5422148222328Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity4Meta AI8Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others28Total54Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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