Beta-carotene to vitamin A conversion efficiency (BCO1 R267S)
BCO1 · rs12934922
0 342823217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others17Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-10.
ClinVar record 1293223NM_017429.3(BCO1):c.801A>T (p.Arg267Ser)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the 267S variant.
A/TCarries one copy of the 267S variant. The discovery study measured this variant mainly in combination with a second BCO1 variant (A379V): people carrying both had 69% lower conversion efficiency (P=0.001) than people with neither, a substantially larger effect than either variant showed on its own. No separate figure for 267S by itself was reported.
T/TCarries two copies of the 267S variant. As with one copy, the discovery study's numbers for this variant are for its combination with a second BCO1 variant (A379V) rather than for 267S in isolation.
Talk to a doctor or a registered dietitian about vitamin A sources, especially if you rely mainly on plant foods for it.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009 · PMID 19103647
Questions about rs12934922
What is rs12934922?
rs12934922 is a single position in the genome, in or near the BCO1 gene. Published research associates it with beta-carotene to vitamin a conversion efficiency (bco1 r267s). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12934922 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12934922 come from?
Leung et al. 2009, FASEB Journal — two common SNPs in BCO1 alter beta-carotene metabolism in female volunteers. PMID 19103647. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 342823217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others17Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Beta-carotene to vitamin A conversion efficiency (BCO1 R267S) (rs12934922). MyGeneLog™. https://www.mygenelog.com/variants/rs12934922