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Who was studied 6,189 European ancestry cases, 931,046 European ancestry controls; replicated in 280 Norwegian ancestry cases, 69,141 Norwegian ancestry controls.
The effect
Each copy of the C allele carried 1.16 times the odds of Sick sinus syndrome (95% confidence interval 1.11-1.21); p = 8 × 10−10.
How common The C allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 16, band 16q22.3 — in an intron of ZFHX3.
What each result means
C/CTwo copies of the version the research linked to Sick sinus syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Sick sinus syndrome. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Sick sinus syndrome. This is the starting point the study compared everyone against.
European heart journal · 2021 · PMID 33580673 · open access
Questions about rs12932445
What is rs12932445?
rs12932445 is a single position in the genome, in or near the ZFHX3 gene. Published research associates it with sick sinus syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12932445 linked to?
On MyGeneLog this position is linked to Sick Sinus Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs12932445 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12932445 come from?
GWAS Catalog, Eur Heart J 2021, PMID:33580673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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