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Eosinophil count

PRSS33 · rs12931183

Where this position leads

Conditions: Colon Polyp, Blood Cell Counts

rs12931183 Condition: Colon Polyp Colon Polyp Condition Condition: Blood Cell Counts Blood Cell Counts Condition rs12931183 rs12931183 PRSS33

What the study found

Who was studied 349,856 European ancestry individuals, 93,063 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0203 lower (95% confidence interval 0.017-0.024); p = 1 × 10−25.

Where it sits Chromosome 16, band 16p13.3 — in the 3′ untranslated region of PRSS33.

What each result means

A/A No copy of the version the research linked to Eosinophil count. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Eosinophil count. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Eosinophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs12931183

What is rs12931183?

rs12931183 is a single position in the genome, in or near the PRSS33 gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12931183 linked to?

On MyGeneLog this position is linked to Colon Polyp, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs12931183 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12931183 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Eosinophil count (rs12931183). MyGeneLog™. https://www.mygenelog.com/variants/rs12931183

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