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Who was studied 38,937 European ancestry morning chronotype individuals, 50,346 European ancestry evening chronotype individuals.
The effect
Each copy of the A allele carried 1.10 times the odds of Morning vs. evening chronotype (95% confidence interval -); p = 2 × 10−12.
How common The A allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 16, band 16q12.2 — in an intron of CASC16.
What each result means
A/ATwo copies of the version the research linked to Morning vs. evening chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Morning vs. evening chronotype. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Morning vs. evening chronotype. This is the starting point the study compared everyone against.
Nature communications · 2016 · PMID 26835600 · open access
Questions about rs12927162
What is rs12927162?
rs12927162 is a single position in the genome, in or near the TOX3 gene. Published research associates it with morning vs. evening chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12927162 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs12927162 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12927162 come from?
GWAS Catalog, Nat Commun 2016, PMID:26835600. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Morning vs. evening chronotype (rs12927162). MyGeneLog™. https://www.mygenelog.com/variants/rs12927162