Sensitive

Non-melanoma skin cancer

MC1R · rs12925026

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs12925026 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin… Condition rs12925026 rs12925026 MC1R

What the study found

Who was studied 5,912 European ancestry cases, 181,740 European ancestry controls.

The effect Each copy of the C allele carried 1.33 times the odds of Non-melanoma skin cancer (95% confidence interval 1.27-1.41); p = 5 × 10−24.

Where it sits Chromosome 16, band 16q24.3 — in an intron of ZNF276.

What each result means

C/C Two copies of the version the research linked to Non-melanoma skin cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Non-melanoma skin cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Non-melanoma skin cancer. This is the starting point the study compared everyone against.
Source

Questions about rs12925026

What is rs12925026?

rs12925026 is a single position in the genome, in or near the MC1R gene. Published research associates it with non-melanoma skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12925026 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs12925026 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12925026 come from?

GWAS Catalog, Nat Commun 2018, PMID:29739929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Non-melanoma skin cancer (rs12925026). MyGeneLog™. https://www.mygenelog.com/variants/rs12925026

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