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Who was studied 55,006 British ancestry males, 61,132 British ancestry females; replicated in 112,425 British ancestry males, 133,936 British ancestry females.
The effect
Each copy of the A allele shifted the measure 0.0224 lower; p = 2 × 10−21.
How common The A allele had a frequency of about 46% in the people studied.
Where it sits Chromosome 15, band 15q24.1 — in an intron of LOXL1.
What each result means
A/ATwo copies of the version the research linked to Body fat distribution (trunk fat ratio). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Body fat distribution (trunk fat ratio). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Body fat distribution (trunk fat ratio). This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 30664634 · open access
Questions about rs12905253
What is rs12905253?
rs12905253 is a single position in the genome, in or near the LOXL1 gene. Published research associates it with body fat distribution (trunk fat ratio). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12905253 linked to?
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.
Does having rs12905253 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12905253 come from?
GWAS Catalog, Nat Commun 2019, PMID:30664634. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Body fat distribution (trunk fat ratio) (rs12905253). MyGeneLog™. https://www.mygenelog.com/variants/rs12905253