Standard

Body mass index

near ZNF280D · rs12903746

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

rs12903746 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs12903746 rs12903746 near ZNF280D

What the study found

Who was studied 359,983 European ancestry individuals, 163,835 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0121 lower (95% confidence interval 0.0082-0.016); p = 8 × 10−10.

Where it sits Chromosome 15, band 15q21.3 — between genes, 80.4 kb from ZNF280D.

What each result means

C/C No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs12903746

What is rs12903746?

rs12903746 is a single position in the genome, in or near the near ZNF280D gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12903746 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs12903746 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12903746 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs12903746). MyGeneLog™. https://www.mygenelog.com/variants/rs12903746

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