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Hematocrit

near RPL32P30 · rs12902050

Where this position leads

Condition: Blood Cell Counts

rs12902050 Condition: Blood Cell Counts Blood Cell Counts Condition rs12902050 rs12902050 near RPL32P30

What the study found

Who was studied 350,475 European ancestry individuals, 153,015 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0181 higher (95% confidence interval 0.014-0.022); p = 6 × 10−16.

Where it sits Chromosome 15, band 15q21.2 — between genes, 5.5 kb from RPL32P30.

What each result means

C/C Two copies of the version the research linked to Hematocrit. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Hematocrit. That is a smaller link than two copies.
T/T No copy of the version the research linked to Hematocrit. This is the starting point the study compared everyone against.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs12902050

What is rs12902050?

rs12902050 is a single position in the genome, in or near the near RPL32P30 gene. Published research associates it with hematocrit. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12902050 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs12902050 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12902050 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hematocrit (rs12902050). MyGeneLog™. https://www.mygenelog.com/variants/rs12902050

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