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Pulmonary function

THSD4 · rs12899618

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 20,288 European ancestry individuals; replicated in up to 54,276 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.06 s.d. higher (95% confidence interval 0.044-0.076); p = 7 × 10⁻¹⁵.

How common The G allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 15, band 15q23 — in an intron of THSD4.

What each result means

A/A No copy of the version the research linked to Pulmonary function. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Pulmonary function. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Pulmonary function. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies five loci associated with lung function

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W

and 83 more — show all

Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo N, Spector TD, Polasek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K, Cooper MN, James AL, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S, McKeever TM, Pavord ID, MacLeod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C, Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP, Tobin MD

Wellcome Trust Case Control Consortium · NSHD Respiratory Study Team

Nature genetics · 2010 · PMID 20010834

Questions about rs12899618

What is rs12899618?

rs12899618 is a single position in the genome, in or near the THSD4 gene. Published research associates it with pulmonary function. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12899618 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs12899618 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12899618 come from?

GWAS Catalog, Nat Genet 2009, PMID:20010834. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary function (rs12899618). MyGeneLog™. https://www.mygenelog.com/variants/rs12899618

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