Who was studied 14,825 European ancestry cases, 44,000 European and unknown ancestry cases, 2,680 cases, 380,970 European ancestry controls, 123,504 European and unknown ancestry controls, 73,242 controls.
The effect
Each copy of the T allele carried 1.06 times the odds of Myocardial infarction (95% confidence interval 1.04-1.08); p = 3 × 10−9.
How common The T allele had a frequency of about 83% in the people studied.
Where it sits Chromosome 14, band 14q32.2 — in an intron of HHIPL1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Myocardial infarction — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myocardial infarction.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myocardial infarction compared to the general population.
rs12897285 is a single position in the genome, in or near the HHIPL1 gene. Published research associates it with myocardial infarction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12897285 linked to?
On MyGeneLog this position is linked to Myocardial Infarction. The research behind each link, and its sources, are set out on that condition page.
Does having rs12897285 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12897285 come from?
GWAS Catalog, European heart journal 2021, PMID:33532862. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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