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Who was studied 106,772 European ancestry cases, 239,773 European ancestry controls; replicated in 83,335 cases, 34,934 controls.
The effect
Each copy of the A allele carried 1.05 times the odds of Allergic disease (asthma, hay fever or eczema) (95% confidence interval 1.035-1.061); p = 1 × 10−12.
How common The A allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 14, band 14q32.32 — between genes, 4.8 kb from TRAF3.
What each result means
A/ATwo copies of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). This is the starting point the study compared everyone against.
Human molecular genetics · 2019 · PMID 31361310 · open access
Questions about rs12887759
What is rs12887759?
rs12887759 is a single position in the genome, in or near the near TRAF3 gene. Published research associates it with allergic disease (asthma, hay fever or eczema). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12887759 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs12887759 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12887759 come from?
GWAS Catalog, Human molecular genetics 2019, PMID:31361310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Allergic disease (asthma, hay fever or eczema) (rs12887759). MyGeneLog™. https://www.mygenelog.com/variants/rs12887759