Standard

Height

SYNE2 · rs12881815

Where this position leads

Condition: Height

rs12881815 Condition: Height Height Condition rs12881815 rs12881815 SYNE2

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0189 higher (95% confidence interval 0.016-0.022); p = 8 × 10−39.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 14, band 14q23.2 — a missense change in SYNE2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Height compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Height.
G/G Published research associates this genotype with typical/baseline likelihood of Height — no copies of the reported risk allele.
Source

Questions about rs12881815

What is rs12881815?

rs12881815 is a single position in the genome, in or near the SYNE2 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12881815 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs12881815 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12881815 come from?

GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (rs12881815). MyGeneLog™. https://www.mygenelog.com/variants/rs12881815

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