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Who was studied 340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0304 higher (95% confidence interval 0.02-0.04); p = 3 × 10−9.
Where it sits Chromosome 11, band 11q12.1 — in an intron of OSBP.
What each result means
A/ANo copy of the version the research linked to Insulin-like growth factor 1 levels. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Insulin-like growth factor 1 levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Insulin-like growth factor 1 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs1287449
What is rs1287449?
rs1287449 is a single position in the genome, in or near the OSBP gene. Published research associates it with insulin-like growth factor 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1287449 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs1287449 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1287449 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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