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Granulocyte percentage of myeloid white cells

near TNFSF13B · rs12874404

Where this position leads

Condition: Blood Cell Counts

rs12874404 Condition: Blood Cell Counts Blood Cell Counts Condition rs12874404 rs12874404 near TNFSF13B

What the study found

Who was studied 169,545 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0465 higher (95% confidence interval 0.031-0.062); p = 4 × 10−9.

How common The G allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 13, band 13q33.3 — in an intron of LOC105370355.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Granulocyte percentage of myeloid white cells — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Granulocyte percentage of myeloid white cells.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Granulocyte percentage of myeloid white cells compared to the general population.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs12874404

What is rs12874404?

rs12874404 is a single position in the genome, in or near the near TNFSF13B gene. Published research associates it with granulocyte percentage of myeloid white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12874404 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs12874404 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12874404 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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