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Its strongest genetic-study result is p = 10−9, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 592 Ashkenazi Jewish ancestry cases, 505 Ashkenazi Jewish ancestry controls, 36,989 cases, 113,075 controls.
The effect
Each copy of the A allele carried 1.07 times the odds of Schizophrenia; p = 5 × 10−9.
Where it sits Chromosome 12, band 12p13.33 — in an intron of CACNA1C.
What each result means
A/ATwo copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015 · PMID 26198764
Questions about rs12823424
What is rs12823424?
rs12823424 is a single position in the genome, in or near the CACNA1C gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12823424 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12823424 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12823424 come from?
GWAS Catalog, Am J Med Genet B Neuropsychiatr Genet 2015, PMID:26198764. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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