Sensitive

Squamous cell lung cancer

RAD52 · rs12822733

Where this position leads

What the study found

Who was studied 4,513 East Asian ancestry cases, 225,690 East Asian ancestry controls, 6,855 European ancestry cases, 260,520 European ancestry controls.

The effect Each copy of the C allele carried 1.15 times the odds of Squamous cell lung cancer (95% confidence interval 1.1-1.2); p = 4 × 10⁻¹¹.

How common The C allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 12, band 12p13.33 — in an intron of RAD52.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Squamous cell lung cancer compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Squamous cell lung cancer.

G/G Published research associates this genotype with typical/baseline likelihood of Squamous cell lung cancer — no copies of the reported risk allele.

Source

Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer

Zhu M, Zhang C, Han Y, Jin C, Miao S, Zhang J, Gong L, Mou Y, Ji C, Fu Y, Zhang E, Yu C

and 17 more — show all

Sun D, Jiang Y, Chen J, Yang L, Chen Y, Du H, Walters R, Millwood I, Dai J, Chen Z, Hu Z, Lv J, Jin G, Amos CI, Shen H, Li L, Ma H

Genome medicine · 2026 · PMID 42152146 · open access

Questions about rs12822733

What is rs12822733?

rs12822733 is a single position in the genome, in or near the RAD52 gene. Published research associates it with squamous cell lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12822733 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12822733 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12822733 come from?

GWAS Catalog, Genome medicine 2026, PMID:42152146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Squamous cell lung cancer (rs12822733). MyGeneLog™. https://www.mygenelog.com/variants/rs12822733

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