Standard
FEV1
CCND2-AS1 · rs12811814
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 321,047 European ancestry individuals; replicated in 79,005 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0149 higher (95% confidence interval 0.01-0.02); p = 3 × 10−10.
How common The T allele had a frequency of about 46% in the people studied.
Where it sits Chromosome 12, band 12p13.32 — between genes, 35.1 kb from HSPA8P5.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of FEV1 — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with FEV1.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of FEV1 compared to the general population.
Source
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
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Guyatt AL,
Erzurumluoglu AM,
Jackson VE,
Hobbs BD,
Melbourne CA,
Batini C,
Fawcett KA,
Song K,
Sakornsakolpat P,
Li X,
Boxall R
and 99 more — show all
Reeve NF,
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Wielscher M,
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Kentistou KA,
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Sun BB,
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Parker MM,
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Sparrow D,
Tal-Singer R,
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Whittaker JC,
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Schulz H,
James AL,
Wilson JF,
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Zeggini E,
Jarvelin MR,
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Silverman EK,
Hayward C,
Morris AP,
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Hall IP,
Tobin MD,
Wain LV
Nature genetics · 2019 · PMID 30804560 · open access
Questions about rs12811814
What is rs12811814?
rs12811814 is a single position in the genome, in or near the CCND2-AS1 gene. Published research associates it with fev1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12811814 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12811814 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
FEV1 (rs12811814). MyGeneLog™. https://www.mygenelog.com/variants/rs12811814
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