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Medication use (diuretics)

SPI1 · rs12801188

Where this position leads

Condition: Medication Use as a Genetic Trait

What the study found

Who was studied 34,453 European ancestry cases, 194,633 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0559 higher (95% confidence interval 0.04-0.072); p = 9 × 10⁻¹².

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 11, band 11p11.2 — in an intron of SPI1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (diuretics) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (diuretics).

G/G Published research associates this genotype with typical/baseline likelihood of Medication use (diuretics) — no copies of the reported risk allele.

Source

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu Y, Byrne EM, Zheng Z, Kemper KE, Yengo L, Mallett AJ, Yang J, Visscher PM, Wray NR

Nature communications · 2019 · PMID 31015401 · open access

Questions about rs12801188

What is rs12801188?

rs12801188 is a single position in the genome, in or near the SPI1 gene. Published research associates it with medication use (diuretics). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12801188 linked to?

On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.

Does having rs12801188 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12801188 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Medication use (diuretics) (rs12801188). MyGeneLog™. https://www.mygenelog.com/variants/rs12801188

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