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Who was studied 8,508 European ancestry individuals, 1,539 Han Chinese ancestry individuals, 843 African American individuals, 445 Hispanic individuals; replicated in 215,234 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.012 lower (95% confidence interval 0.0081-0.0159); p = 2 × 10−8.
How common The T allele had a frequency of about 71% in the people studied.
Where it sits Chromosome 11, band 11p15.2 — in an intron of SOX6.
What each result means
C/CNo copy of the version the research linked to Bone mineral density. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Bone mineral density. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs12800228 is a single position in the genome, in or near the SOX6 gene. Published research associates it with bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12800228 linked to?
On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.
Does having rs12800228 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12800228 come from?
GWAS Catalog, Journal of human genetics 2021, PMID:32929176. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bone mineral density (rs12800228). MyGeneLog™. https://www.mygenelog.com/variants/rs12800228