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High-density lipoprotein levels (MTAG)

near TNKS1BP1 · rs12797544

What the study found

Who was studied 361,194 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0178 lower (95% confidence interval 0.012-0.023); p = 4 × 10−10.

Where it sits Chromosome 11, band 11q12.1 — between genes, 17.3 kb from TNKS1BP1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of High-density lipoprotein levels (MTAG) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with High-density lipoprotein levels (MTAG).
G/G Published research associates this genotype with typical/baseline likelihood of High-density lipoprotein levels (MTAG) — no copies of the reported risk allele.
Source

Questions about rs12797544

What is rs12797544?

rs12797544 is a single position in the genome, in or near the near TNKS1BP1 gene. Published research associates it with high-density lipoprotein levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12797544 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12797544 come from?

GWAS Catalog, Nature communications 2022, PMID:36376304. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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High-density lipoprotein levels (MTAG) (rs12797544). MyGeneLog™. https://www.mygenelog.com/variants/rs12797544

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