Standard
Homocysteine levels
CUBN · rs12780845
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Homocysteine levels compared to the general population. (GWAS Catalog, Am J Clin Nutr 2013, PMID:23824729)
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Homocysteine levels. (GWAS Catalog, Am J Clin Nutr 2013, PMID:23824729)
G/G
Published research associates this genotype with typical/baseline likelihood of Homocysteine levels — no copies of the reported risk allele. (GWAS Catalog, Am J Clin Nutr 2013, PMID:23824729)
Source
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
van Meurs JB,
Pare G,
Schwartz SM,
Hazra A,
Tanaka T,
Vermeulen SH,
Cotlarciuc I,
Yuan X,
Mälarstig A,
Bandinelli S,
Bis JC,
Blom H
and 46 more — show all
Brown MJ,
Chen C,
Chen YD,
Clarke RJ,
Dehghan A,
Erdmann J,
Ferrucci L,
Hamsten A,
Hofman A,
Hunter DJ,
Goel A,
Johnson AD,
Kathiresan S,
Kampman E,
Kiel DP,
Kiemeney LA,
Chambers JC,
Kraft P,
Lindemans J,
McKnight B,
Nelson CP,
O'Donnell CJ,
Psaty BM,
Ridker PM,
Rivadeneira F,
Rose LM,
Seedorf U,
Siscovick DS,
Schunkert H,
Selhub J,
Ueland PM,
Vollenweider P,
Waeber G,
Waterworth DM,
Watkins H,
Witteman JC,
den Heijer M,
Jacques P,
Uitterlinden AG,
Kooner JS,
Rader DJ,
Reilly MP,
Mooser V,
Chasman DI,
Samani NJ,
Ahmadi KR
The American journal of clinical nutrition · 2013 · PMID 23824729
Questions about rs12780845
What is rs12780845?
rs12780845 is a single position in the genome, in or near the CUBN gene. Published research associates it with homocysteine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12780845 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12780845 come from?
GWAS Catalog, Am J Clin Nutr 2013, PMID:23824729. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants