Sensitive

Type 2 diabetes

CDC123 · rs12779790

Where this position leads

What the study found

Who was studied 4,549 European ancestry cases, 5,579 European ancestry controls; replicated in 24,194 European ancestry cases, 55,598 European ancestry controls.

The effect Each copy of the G allele carried 1.11 times the odds of Type 2 diabetes (95% confidence interval 1.07-1.14); p = 1 × 10⁻¹⁰.

How common The G allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 10, band 10p13 — between genes, 35.4 kb from CDC123.

What each result means

A/A No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB

and 86 more — show all

Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D

Wellcome Trust Case Control Consortium

Nature genetics · 2008 · PMID 18372903

Questions about rs12779790

What is rs12779790?

rs12779790 is a single position in the genome, in or near the CDC123 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12779790 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs12779790 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12779790 come from?

GWAS Catalog, Nature genetics 2008, PMID:18372903. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs12779790). MyGeneLog™. https://www.mygenelog.com/variants/rs12779790

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