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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 5,321 European ancestry cases, 16,666 European ancestry controls; replicated in 2,237 cases, 3,461 controls.
The effect
Each copy of the C allele carried 1.22 times the odds of B-cell acute lymphoblastic leukaemia (95% confidence interval 1.15-1.29); p = 6 × 10−13.
How common The C allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 10, band 10q26.13 — in an intron of LHPP.
What each result means
C/CTwo copies of the version the research linked to B-cell acute lymphoblastic leukaemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to B-cell acute lymphoblastic leukaemia. That is a smaller link than two copies.
T/TNo copy of the version the research linked to B-cell acute lymphoblastic leukaemia. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31767839 · open access
Questions about rs12779301
What is rs12779301?
rs12779301 is a single position in the genome, in or near the LHPP gene. Published research associates it with b-cell acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12779301 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12779301 come from?
GWAS Catalog, Nature communications 2019, PMID:31767839. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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