CASP7 · rs12777332
Where this position leads
Condition: Cataract
What the study found
Who was studied 38,996 female cases, 283,185 female controls, 28,848 male cases, 234,414 male controls; replicated in 211,030 female cases, 1,623,785 female controls, 136,179 male cases, 1,263,461 male controls.
The effect Each copy of the G allele carried 1.04 times the odds of Cataracts (95% confidence interval 1.03-1.05); p = 5 × 10−15.
Where it sits Chromosome 10, band 10q25.3 — in an intron of CASP7.
rs12777332 is a single position in the genome, in or near the CASP7 gene. Published research associates it with cataracts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cataract. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2021, PMID:34127677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cataracts (rs12777332). MyGeneLog™. https://www.mygenelog.com/variants/rs12777332