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Who was studied 929 Swedish ancestry cases, 935 Swedish ancestry controls.
The effect
Each copy of the T allele carried 0.66 times the odds of Parkinson's disease (95% confidence interval 0.52-0.8); p = 1 × 10−8.
How common The T allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 10, band 10q26.12 — in an intron of PLPP4.
What each result means
C/CNo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of Parkinson's disease · 2022 · PMID 34776419 · open access
Questions about rs12771445
What is rs12771445?
rs12771445 is a single position in the genome, in or near the PLPP4 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12771445 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12771445 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12771445 come from?
GWAS Catalog, Journal of Parkinson's disease 2022, PMID:34776419. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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