0 332217223113Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,778 European ancestry cases, 5,376 European ancestry controls; replicated in 1,029 European ancestry cases, 1,065 European ancestry controls.
The effect
Each copy of the G allele carried 1.17 times the odds of Essential tremor (95% confidence interval 1.09-1.26); p = 1 × 10−8.
How common The G allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 10, band 10q21.3 — in an intron of LRRTM3.
What each result means
G/GTwo copies of the version the research linked to Essential tremor. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Essential tremor. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Essential tremor. This is the starting point the study compared everyone against.
Brain : a journal of neurology · 2016 · PMID 27797806 · open access
Questions about rs12764057
What is rs12764057?
rs12764057 is a single position in the genome, in or near the CTNNA3 gene. Published research associates it with essential tremor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12764057 linked to?
On MyGeneLog this position is linked to Essential Tremor. The research behind each link, and its sources, are set out on that condition page.
Does having rs12764057 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12764057 come from?
GWAS Catalog, Brain 2016, PMID:27797806. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 332217223113Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total33Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.