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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 403,928 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0152 lower (95% confidence interval 0.01-0.02); p = 5 × 10−9.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.
What each result means
A/ATwo copies of the version the research linked to Cigarettes smoked per day (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Cigarettes smoked per day (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cigarettes smoked per day (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30643251 · open access
Questions about rs12760107
What is rs12760107?
rs12760107 is a single position in the genome, in or near the PDE4B gene. Published research associates it with cigarettes smoked per day (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12760107 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12760107 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cigarettes smoked per day (MTAG) (rs12760107). MyGeneLog™. https://www.mygenelog.com/variants/rs12760107