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Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis)

KCNK3 · rs1275922

What the study found

Who was studied at least 837,415 European ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 2 × 10−8.

How common The G allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 2, band 2p23.3 — in an intron of KCNK3.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) compared to the general population.
Source

Questions about rs1275922

What is rs1275922?

rs1275922 is a single position in the genome, in or near the KCNK3 gene. Published research associates it with aging traits (healthspan, parental lifespan or longevity) (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1275922 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1275922 come from?

GWAS Catalog, Nature communications 2020, PMID:32678081. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) (rs1275922). MyGeneLog™. https://www.mygenelog.com/variants/rs1275922

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