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Who was studied 122,644 European ancestry individuals (MTAG effective sample size boosted by proton density fat fraction samples).
The effect
Each copy of the A allele shifted the measure 0.0385 lower (95% confidence interval 0.028-0.049); p = 3 × 10−12.
How common The A allele had a frequency of about 87% in the people studied.
Where it sits Chromosome 1, band 1p36.11 — in the 3′ untranslated region of ZDHHC18.
What each result means
A/ATwo copies of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Metabolic dysfunction-associated steatotic liver disease (MTAG). This is the starting point the study compared everyone against.
Science advances · 2026 · PMID 41686896 · open access
Questions about rs12747620
What is rs12747620?
rs12747620 is a single position in the genome, in or near the ZDHHC18 gene. Published research associates it with metabolic dysfunction-associated steatotic liver disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12747620 linked to?
On MyGeneLog this position is linked to Nonalcoholic Fatty Liver Disease (NAFLD). The research behind each link, and its sources, are set out on that condition page.
Does having rs12747620 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12747620 come from?
GWAS Catalog, Science advances 2026, PMID:41686896. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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