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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.506 higher (95% confidence interval 0.39-0.63); p = 6 × 10−16.
Where it sits Chromosome 1, band 1q31.3 — in an intron of CFHR4.
What each result means
G/GNo copy of the version the research linked to Complement C1s subcomponent levels. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Complement C1s subcomponent levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Complement C1s subcomponent levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2017 · PMID 28240269 · open access
Questions about rs12734260
What is rs12734260?
rs12734260 is a single position in the genome, in or near the CFHR4 gene. Published research associates it with complement c1s subcomponent levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12734260 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12734260 come from?
GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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