Sensitive

Alzheimer's disease or family history of Alzheimer's disease

KDM2A · rs1273071898

Where this position leads

Condition: Alzheimer's Disease

rs1273071898 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs1273071898 rs1273071898 KDM2A

What the study found

Who was studied 37,075 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry cases, 367,392 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 2 × 10−10.

Where it sits Chromosome 11, band 11q13.2 — in an intron of KDM2A.

What each result means

C/C Two copies of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. This is the starting point the study compared everyone against.
Source

Questions about rs1273071898

What is rs1273071898?

rs1273071898 is a single position in the genome, in or near the KDM2A gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1273071898 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs1273071898 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1273071898 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or family history of Alzheimer's disease (rs1273071898). MyGeneLog™. https://www.mygenelog.com/variants/rs1273071898

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