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Who was studied 6,333 European ancestry cases, 15,056 European ancestry controls; replicated in 15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios.
The effect
Each copy of the C allele carried 1.11 times the odds of Crohn's disease (95% confidence interval 1.05-1.16); p = 3 × 10−9.
How common The C allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 10, band 10p15.1 — in an intron of IL2RA.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs12722489 is a single position in the genome, in or near the IL2RA gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12722489 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12722489 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12722489 come from?
GWAS Catalog, Nat Genet 2010, PMID:21102463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 433228213220Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot2Amazon1Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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