TNFRSF11A · rs12721434
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 47,745 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.355 higher (95% confidence interval 0.26-0.45); p = 4 × 10−16.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 18, band 18q21.33 — in the 3′ untranslated region of TNFRSF11A.
What ClinVar records
Classification
Uncertain significance for Paget disease of bone 2, early-onset, Autosomal recessive osteopetrosis 7; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-01-13.
ClinVar record 889184 NM_003839.4(TNFRSF11A):c.*1368C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs12721434 is a single position in the genome, in or near the TNFRSF11A gene. Published research associates it with tnfrsf11a protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TNFRSF11A protein levels (rs12721434). MyGeneLog™. https://www.mygenelog.com/variants/rs12721434